Author/Authors :
Tsuboi، نويسنده , , Makoto and Etoh، نويسنده , , Hideo and Yomoda، نويسنده , , Yuya and Kato، نويسنده , , Kyuki and Kato، نويسنده , , Hideaki and Kulkarni، نويسنده , , Aditya and Terada، نويسنده , , Yukimasa and Maoka، نويسنده , , Takashi and Mori، نويسنده , , Hironobu and Inakuma، نويسنده , , Takahiro، نويسنده ,
Abstract :
The in vitro reactivity of lutein toward peroxynitrite was investigated, and the reaction products produced by scavenging with peroxynitrite were analyzed. A novel lutein-6H-1,2-oxazine (1) along with 14-s-cis-15-nitirolutein (2) and 14′-s-cis-15′-nitrolutein (3) was isolated from the products of the reaction of lutein with peroxynitrite. These results indicate that lutein is able to capture peroxynitrite and nitrogen dioxide radicals from their molecules to form oxazine or nitrocarotenoids.
Keywords :
Reaction with peroxynitrite , 2-oxazine , 14?-s-cis-15?-Nitrolutein , 14-s-cis-15-Nitrolutein , Lutein , Lutein-6H-1
