Title of article :
One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and SNAr reaction
Author/Authors :
Gellerman، نويسنده , , Gary and Gaisin، نويسنده , , Vladimir and Brider، نويسنده , , Tamara، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Abstract :
A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and SNAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening.
Keywords :
9-aminoacridine , reductive alkylation , one-pot synthesis , nucleophilic substitution
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
