Title of article
Synthesis of aspergillide A from a synthetic intermediate of aspergillide B
Author/Authors
Nagasawa، نويسنده , , Tomohiro and Kuwahara، نويسنده , , Shigefumi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
875
To page
877
Abstract
The first synthesis of aspergillide A, a cytotoxin produced by a marine-derived fungus, has been achieved from a synthetic intermediate of aspergillide B by using a proline-mediated epimerization of a 2,6-trans-substituted tetrahydropyran-2-acetaldehyde intermediate into the corresponding cis-isomer via a retro-oxy-Michael/oxy-Michael sequence as the key transformation.
Keywords
Aspergillide , Cytotoxic , Epimerization , macrolide
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1871024
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