Author/Authors :
Mochizuki، نويسنده , , Tetsuya and Tanimura، نويسنده , , Akihiko and Nezu، نويسنده , , Akihiro and Ito، نويسنده , , Mika and Abe، نويسنده , , Hiroshi and Ito، نويسنده , , Yoshihiro and Arisawa، نويسنده , , Mitsuhiro and Shuto، نويسنده , , Satoshi، نويسنده ,
Abstract :
Indole derivatives 3a and 3b of adenophostin A (2) in which the adenine of 2 was replaced with indole or 4-fluoroindole was designed as potential inositol trisphosphate receptor ligands. These target compounds were successfully synthesized from the key disaccharide unit 6. Biological evaluation showed that 3b selectively activates IP3R1, a subtype of IP3 receptors.
