Author/Authors :
Abassi، Fariba نويسنده Dept. of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia , , Ghavam، Farrokh نويسنده , , Norouzinia، Farahnaz نويسنده Dept. of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia , , Pourali، Reza نويسنده Department of Community Medicine, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran , , Jalvand، Monireh نويسنده Dept. of Health Education,Faculty of Medicine, Urmia University of Medical Sciences, Urmia ,
Abstract :
Background and Objective: Microscopic evaluation of cervicovaginal smears (Pap smear)
plays an essential role in detection of preneoplastic and neoplastic lesions of uterine cervix. A wide
spectrum of changes is seen in Pap smears. Interpretation of intermediate changes which resulting
in observation of so- called ASCUS is difficult. ASCUS is defined as a cellular change that is more
marked than typical reactive change but lack features diagnostic of intraepithelial neoplasia. The
aim of this study was determination of reliable cytological parameters to identifying real nature of
ASCUS.
Patients and Methods: In this descriptive, cross sectional study, all Pap smears with presence of
ASCUS, which followed by biopsy samples in Urmia, Shahid Matahari hospital during March 1999
to December 2002 were reviewed. In this regard, 17 parameters of cytoplasm, nuclei and smear
background were considered and data were analyzed by SPSS and Chi Square test.
Results: Four parameters of irregular nuclear contour, increased nucleo- cytoplasmic ratio,
cytoplasmic vacuolization and dirty background are highly suggestive of dysplasia.
Conclusion: It is important to consider that to find out the real nature of ASCUS a group of
parameters are more helpful than a single one. In addition, a single Pap smear is not enough for this
purpose and further investigation is required.
