Author/Authors :
Gomez، نويسنده , , Laurent and Wu، نويسنده , , Jiejun and Mani، نويسنده , , Neelakandha S. and Basu، نويسنده , , Sudip and Moravek، نويسنده , , Josef and Breitenbucher، نويسنده , , J. Guy، نويسنده ,
Abstract :
Attempts to prepare JNJ 26273364, a highly functionalized pyrazole-based CCK1 receptor antagonist, using a carboxylation reaction led to a series of unexpected results. This work demonstrated the unique reactivity and stability of the highly functionalized Z-alkene functionality present around the pyrazole.
