Stereoselective synthesis of dendrobate alkaloid (+)-241D and its C-4 epimer

An efficient stereoselective synthesis of dendrobate alkaloid (+)-241D and its C-4 epimer was achieved from the inexpensive, commercially available starting material decanal (10) in an overall yield of 21.9% and 21.1%, respectively. This synthesis utilizes the key steps of Maruoka asymmetric allylation, one-pot epoxidation followed by nucleophilic addition of an organomagnesium reagent (Forsyth’s protocol) and subsequent functional group transformations.