Author/Authors :
Driver، نويسنده , , Cathryn H.S. and Balogun، نويسنده , , Mohammed O. and Toschi، نويسنده , , Gianna and Verschoor، نويسنده , , Jan A. and Baird، نويسنده , , Mark S. and Pilcher، نويسنده , , Lynne A.، نويسنده ,
Abstract :
A new method for the stereoselective synthesis of the (R,R)-β-hydroxy-α-alkyl fatty acid fragment of mycolic acids, via an asymmetric anti-aldol reaction is reported. The ‘mycolic acid motif’ fragment was prepared in three steps and >98% ee.
Keywords :
Tuberculosis , Mycolic acid , Mycolic acid motif , Asymmetric anti-aldol reaction
