Title of article :
Synthesis of sterically hindered 3,5,5-trimethyl 2,6-dioxo tetrahydro pyrimidine as HCV protease inhibitors
Author/Authors :
Nair، نويسنده , , Latha G. and Bogen، نويسنده , , Stephane and Doll، نويسنده , , Ronald J. and Shih، نويسنده , , N.-Y. and Njoroge، نويسنده , , F. George، نويسنده ,
Abstract :
An efficient route for the synthesis of sterically hindered substituted and unsubstituted 2,6-dioxo tetrahydropyrimidines from amine 1 is described. These analogs are active against HCV NS3 serine protease. The biological data for some of the representative examples are also reported.
