Title of article
A novel synthesis of 3-(substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones
Author/Authors
Turbiak، نويسنده , , Anjanette J. and Kampf، نويسنده , , Jeff W. and Hollis Showalter، نويسنده , , H.D.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
1326
To page
1328
Abstract
An improved synthesis of 3-(substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones, a known subclass of 4-deazatoxoflavins, is reported. The approach involves treatment of 3-methyl-6-(1-methylhydrazinyl)uracil with representative phenyl and alkyl glyoxal monohydrates, which in turn are obtained by selenium dioxide oxidation of the corresponding phenyl and alkyl methyl ketones. The first entry into 4-monosubstituted isomers is also reported.
Keywords
4-Deazatoxoflavin , cyclizations , 6-(1-Methylhydrazinyl)uracil , 5-c]pyridazine-5 , 7(1H , 6H)-dione , Phenylglyoxal
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1871359
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