Author/Authors :
Schroeder، نويسنده , , Gretchen M. and Marshall، نويسنده , , Sydney and Wan، نويسنده , , Honghe and Purandare، نويسنده , , Ashok V.، نويسنده ,
Abstract :
Improved conditions for converting amides into 1,5-disubstituted tetrazoles are described. The optimum reaction conditions [diisopropyl azodicarboxylate (DIAD), diphenylphosphoryl azide (DPPA), and diphenyl-2-pyridyl phosphine in THF at 45 °C] converted sterically hindered amides to their corresponding tetrazoles in good yield.
