Author/Authors :
Vogel، نويسنده , , Sophie and Bantreil، نويسنده , , Xavier and Maitro، نويسنده , , Guillaume and Prestat، نويسنده , , Guillaume and Madec، نويسنده , , David and Poli، نويسنده , , Giovanni، نويسنده ,
Abstract :
Asymmetric intramolecular palladium-catalyzed allylic alkylation allowing access to disubstituted sulfinyl γ-lactams is described. The use of unsaturated amides bearing a sulfinyl group of defined absolute configuration together with enantiopure BINAP as the ligand in a biphasic medium provided good diastereoselectivities with clear solvent effect.
Keywords :
Catalysis , Lactam , allylic alkylation , Sulfoxide , PALLADIUM , enantioselective
