Title of article
Palladium-catalyzed intramolecular allylic alkylation of α-sulfinyl carbanions: a new asymmetric route to enantiopure γ-lactams
Author/Authors
Vogel، نويسنده , , Sophie and Bantreil، نويسنده , , Xavier and Maitro، نويسنده , , Guillaume and Prestat، نويسنده , , Guillaume and Madec، نويسنده , , David and Poli، نويسنده , , Giovanni، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
1459
To page
1461
Abstract
Asymmetric intramolecular palladium-catalyzed allylic alkylation allowing access to disubstituted sulfinyl γ-lactams is described. The use of unsaturated amides bearing a sulfinyl group of defined absolute configuration together with enantiopure BINAP as the ligand in a biphasic medium provided good diastereoselectivities with clear solvent effect.
Keywords
Catalysis , Lactam , allylic alkylation , Sulfoxide , PALLADIUM , enantioselective
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1871444
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