Author/Authors :
Gabriele، نويسنده , , Bartolo and Veltri، نويسنده , , Lucia and Mancuso، نويسنده , , Raffaella and Plastina، نويسنده , , Pierluigi and Salerno، نويسنده , , Giuseppe and Costa، نويسنده , , Mirco، نويسنده ,
Abstract :
A novel and convenient approach to furan-3-carboxylic esters 2 is presented, based on palladium-catalyzed direct oxidative carbonylation of readily available 3-yne-1,2-diols 1. The process, corresponding to a sequential combination between a 5-endo-dig heterocyclodehydration step and an oxidative alkoxycarbonylation stage, is catalyzed by PdI2 in conjunction with an excess of KI under relatively mild conditions (100 °C in ROH under 40 atm of a 4:1 mixture of CO-air).
