Author/Authors :
Mascitti، نويسنده , , Vincent B. Robinson، نويسنده , , Ralph P. and Préville، نويسنده , , Cathy and Thuma، نويسنده , , Benjamin A. and Carr، نويسنده , , Christopher L. and Reese، نويسنده , , Matthew R. and Maguire، نويسنده , , Robert J. and Leininger، نويسنده , , Michael T. and Lowe، نويسنده , , André and Steppan، نويسنده , , Claire M.، نويسنده ,
Abstract :
Several syntheses of C-5-spirocycle-containing C-glycosides are discussed. A multigram-scale synthesis capitalizing on a one-pot aldol-Cannizzaro sequence is described. Spiro oxetane formation using an unprotected penta-ol C-glycoside as substrate is also exemplified. Functional assessment of these compounds for potency and selectivity was evaluated at human SGLT2 and SGLT1.
