Author/Authors :
Paul LaBeaume، نويسنده , , Paul and Placzek، نويسنده , , Michael and Daniels، نويسنده , , Mathew and Kendrick، نويسنده , , Ian and Ng، نويسنده , , Patrick and McNeel، نويسنده , , Melissa and Afroze، نويسنده , , Roushan and Alexander، نويسنده , , Abigail and Thomas، نويسنده , , Rhiannon and Kallmerten، نويسنده , , Amy E. and Jones، نويسنده , , Graham B.، نويسنده ,
Abstract :
Methods for the expeditious fluorination of arenes have been investigated, using readily available fluoride sources. An optimized procedure for microwave-accelerated fluorodenitration has been developed, giving good to excellent yields in less than 10 min, rendering it practical for use in the preparation of F18 labeled ligands for PET imaging. Application of the method in the synthesis of CNS agents is demonstrated, and a practical method for the preparation of substrates is also presented.
Keywords :
Nitrodehalogenation , PET , donepezil , Haloperidol , Fluorodenitration , F18 , microwave
