Direct C-3 arylation of N-acetylindoles with anisoles using phenyliodine bis(trifluoroacetate) (PIFA)

The direct C-3 arylation of N-acetylindoles with anisoles was described in this Letter. In the presence of phenyliodine bis(trifluoroacetate) (PIFA) and BF3·Et2O, the reaction of N-acetylindoles with anisoles provided C-3 arylindoles with high regioselectivity under mild conditions.