Title of article :
A mild titanium-based system for the reduction of amides to aldehydes
Author/Authors :
Laval، نويسنده , , Stéphane and Dayoub، نويسنده , , Wissam and Favre-Réguillon، نويسنده , , Alain and Demonchaux، نويسنده , , Patrice and Mignani، نويسنده , , Gérard and Lemaire، نويسنده , , Marc، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Abstract :
A mild method for the reduction of amides to aldehydes using 1,1,3,3-tetramethyldisiloxane/titanium(IV) isopropoxide reducing system is described. The reaction occurs under mild conditions and allows the reduction of aromatic as well as aliphatic, tertiary amides to the corresponding aldehydes, in good yields. This methodology was extended to the reduction of aromatic secondary and primary amides to the corresponding aldehydes.
Keywords :
1 , 1 , 3-Tetramethyldisiloxane , Aldehydes , Reduction , 3 , Amides , Titanium
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
