Author/Authors :
S. Mohana Roopan، نويسنده , , Selvaraj Mohana and Khan، نويسنده , , Fazlur Rahman Nawaz and Mandal، نويسنده , , Badal Kumar and Suzuki، نويسنده ,
Abstract :
An efficient and regioselective N-alkylation of 4(3H)-pyrimidone with various electrophiles in the presence of Fe nano particle is reported. The catalyst initiates N-alkylation of amides by alkyl chlorides. The reaction of equimolar 4(3H)-pyrimidone and 2-chloro-3-(chloromethyl)quinolines in the presence of KOH and Fe nano particle (5 mol %) in DMSO solution under reflux condition formed 3-[(2-chloroquinolin-3-yl]methyl)pyrimidin-4(3H)ones.
