Author/Authors :
Geng، نويسنده , , Chang-An and Zhang، نويسنده , , Xuemei and Ma، نويسنده , , Yun-Bao and Jiang، نويسنده , , Zhiyong and Luo، نويسنده , , Jie and Zhou، نويسنده , , Jun and Wang، نويسنده , , Hong-Ling and Chen، نويسنده , , Ji-Jun، نويسنده ,
Abstract :
Swerilactones E (1), F (2), and G (3), three unusual lactones with a phenyl group, were isolated from the traditional Chinese herb of Swertia mileensis. Their structures were determined based on extensive spectroscopic analysis and X-ray single crystal crystallography. Our anti-HBV assay on the Hep G 2.2.15 cell line in vitro showed that compounds 1 and 2 exhibited significant inhibitory activities against the secretion of HBsAg with IC50 of 0.22 and 0.70 mM and HBeAg with IC50 of 0.52 and >6.78 mM, respectively.
Keywords :
Swerilactones E–G , Secoiridoid aglycone , Anti HBV activity , Swertia mileensis
