Title of article :
Asymmetric synthesis of (+)-chloriolide
Author/Authors :
Das، نويسنده , , Tapas and Jana، نويسنده , , Nandan and Nanda، نويسنده , , Samik، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Abstract :
An asymmetric synthesis of 12-membered ring macrolide, chloriolide has been accomplished by adopting a linear strategy. Lipase-catalyzed enzymatic kinetic resolution (EKR), asymmetric alkynylation using Trost pro-phenol catalyst followed by Yamaguchi macrolactonization has been successfully employed to achieve the target molecule.
Keywords :
Asymmetric alkynylation , Asymmetric total synthesis , macrolactonization , Medium ring macrolides , Enzymatic kinetic resolution (EKR)
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
