Title of article
Asymmetric synthesis of (+)-chloriolide
Author/Authors
Das، نويسنده , , Tapas and Jana، نويسنده , , Nandan and Nanda، نويسنده , , Samik، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
2644
To page
2647
Abstract
An asymmetric synthesis of 12-membered ring macrolide, chloriolide has been accomplished by adopting a linear strategy. Lipase-catalyzed enzymatic kinetic resolution (EKR), asymmetric alkynylation using Trost pro-phenol catalyst followed by Yamaguchi macrolactonization has been successfully employed to achieve the target molecule.
Keywords
Asymmetric alkynylation , Asymmetric total synthesis , macrolactonization , Medium ring macrolides , Enzymatic kinetic resolution (EKR)
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1872157
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