Author/Authors :
Nakagawa، نويسنده , , Daisuke and Miyashita، نويسنده , , Masaaki and Tanino، نويسنده , , Keiji، نويسنده ,
Abstract :
A new method for constructing the ABCE ring system of azadirachtin in a stereoselective manner was developed. The synthesis of the model compound features (1) stereoselective construction of the highly hindered C8 quaternary center by an intermolecular addition reaction of an allylborane with an aldehyde and (2) construction of the E ring moiety by the Pd-catalyzed Nazarov cyclization.
