Author/Authors :
Bochicchio، نويسنده , , Antonella and Chiummiento، نويسنده , , Lucia and Funicello، نويسنده , , Maria and Lopardo، نويسنده , , Maria Teresa and Lupattelli، نويسنده , , Paolo، نويسنده ,
Abstract :
Acetylation/Sonogashira cross-coupling reaction/cyclization has been carried out in one-pot using a Na2PdCl4/2-(di-tert-butylphosphino)-N-phenylindole/CuI system in TMEDA to give 5-nitro-2-substituted benzo[b]furans in excellent yields. We also describe the extension of this method to 4-EWG-2-bromo-phenols obtaining 2,5-disubstituted-benzo[b]furans in good yields.
Keywords :
2-Br-phenyl acetates , Sonogashira reaction , Pd catalyst , heteroannulation
