Author/Authors :
Gَmez-Vallejo، نويسنده , , Vanessa and Kato، نويسنده , , Koichi and Oliden، نويسنده , , Iosu and Calvo، نويسنده , , Javier and Baz، نويسنده , , Zuriٌe and Borrell، نويسنده , , José I. and Llop، نويسنده , , Jordi، نويسنده ,
Abstract :
In the present Letter, a fast, automated, and reproducible method for the synthesis of S-[13N]nitrosothiols is reported. The labeling strategy is based on trapping [ 13 N ] NO 2 - in an anion exchange resin. The reaction with thiols in acidic media led to the formation of the desired nitrosothiols in short reaction times (60 s) with excellent radiochemical conversions (from 48.7% to 74.5%). Final radiotracers were purified by HPLC. Good radiochemical yields (from 33.8% to 60.6%, decay corrected) and radiochemical purities (>99%) were obtained in all cases. Stability of the labeled compounds was checked.
