Title of article :
Synthesis of isoxazolobenzoxepanes via Michael addition of indoles to nitroalkenes and sequential intramolecular nitrile oxide cycloaddition
Author/Authors :
Ramachandiran، نويسنده , , K. G. Karthikeyan، نويسنده , , K. and Muralidharan، نويسنده , , D. and Perumal، نويسنده , , P.T.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Abstract :
Nitroalkenes derived from O-propargyl salicylaldehyde undergo facile Michael addition with indoles leading to indole-derived Michael adducts. Intramolecular nitrile oxide cycloaddition (INOC) of the Michael adducts results in isoxazolobenzoxepanes in good to excellent yields.
Keywords :
Michael addition , Intramolecular nitrile oxide cycloaddition , Isoxazoles , Benzoxepanes
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
