Author/Authors :
Colombel، نويسنده , , Virginie and Joncour، نويسنده , , Agnès and Thoret، نويسنده , , Sylviane and Dubois، نويسنده , , Joëlle and Bignon، نويسنده , , Jérôme and Wdzieczak-Bakala، نويسنده , , Joanna and Baudoin، نويسنده , , Olivier، نويسنده ,
Abstract :
New dibenzoxepines 5a–i bearing various substituents on B- and C-rings were synthesized in a straightforward manner using a Suzuki–Miyaura coupling, a Grignard addition, and a cyclodehydration as key steps. The antimicrotubule activity of all analogues was evaluated and compared to reference compounds. Compounds 5d–f displayed the highest activity for this type of allocolchicinoids to date.
