Efficient synthesis of 1,4-disubstituted polyfunctional piperazines via a sequential one-pot Ugi/nucleophilic addition five-component reaction

Polyfunctional 1,4-disubstituted piperazines were successfully synthesized stereoselectively via a one-pot, five-component Ugi/nucleophilic addition reaction sequence. Regio- and stereo-selective addition of piperazine to an activated alkyne under catalyst-free conditions and high yields of products are advantages of this method.