Author/Authors :
Panchgalle، نويسنده , , Sharad P. and Jogdand، نويسنده , , Ganesh F. and Chavan، نويسنده , , Subhash P. and Kalkote، نويسنده , , Uttam R.، نويسنده ,
Abstract :
An efficient enantioselective synthesis of (R)-(+)-α-lipoic acid is described, in high optical purity (>97% ee), using l-proline-catalyzed sequential α-aminoxylation and Horner–Wadsworth–Emmons olefination of aldehyde as the key step.
