Author/Authors :
Jung، نويسنده , , Sang Oh and Ahn، نويسنده , , Ji Yeon and Kim، نويسنده , , Sudeok and Yi، نويسنده , , Sujung and Kim، نويسنده , , Mi Hee and Jang، نويسنده , , Hyun Hye and Seo، نويسنده , , Seong Hyeok and Eom، نويسنده , , Min-Sik and Kim، نويسنده , , Seung Kyung and Ryu، نويسنده , , De Hun and Chang، نويسنده , , Suk-Kyu and Han، نويسنده , , Min Su، نويسنده ,
Abstract :
Fluorescein mercury acetate (FMA) derivative can be used as a chemosensor for NADH that plays key roles in cellular energy metabolism and dehydrogenase enzymatic reactions. The sensor recognizes NADH by two mercury metal ions in the compound using the metal–anion interaction and its subsequent binding-induced fluorescence changes of FMA. The FMA can detect an aqueous NADH concentration of approximately 1.0 μM and has a high selectivity over various anions including NAD+, the oxidized form of NADH.
