Author/Authors :
Nagorny، نويسنده , , Pavel and Krauss، نويسنده , , Isaac and Njardarson، نويسنده , , Jَn T. and Perez، نويسنده , , Lucy and Gaul، نويسنده , , Christoph and Yang، نويسنده , , Guangli and Ouerfelli، نويسنده , , Ouathek and Danishefsky، نويسنده , , Samuel J.، نويسنده ,
Abstract :
In the light of recently disclosed crystallographic studies on migrastatin ketone 2 complex with fascin, the structures of migrastatin ketone 2 and migrastatin ether 4 have been re-evaluated by NMR and X-ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirmed that the ‘small molecule’ co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer.
