Title of article :
Synthetic approaches to 5,7-disubstituted imidazo[5,1-f][1,2,4]triazin-4-amines
Author/Authors :
Werner، نويسنده , , Douglas S. and Dong، نويسنده , , Hanqing and Kadalbajoo، نويسنده , , Mridula and Laufer، نويسنده , , Radoslaw S. and Tavares-Greco، نويسنده , , Paula A. and Volk، نويسنده , , Brian R. and Mulvihill، نويسنده , , Mark J. and Crew، نويسنده , , Andrew P.، نويسنده ,
Abstract :
The preparation of 5,7-disubstituted imidazo[5,1-f][1,2,4]triazin-4-amines, exemplified by 5-[3-(benzyloxy)phenyl]-7-cyclobutylimidazo[5,1-f][1,2,4]triazin-4-amine, was developed through a linear and three convergent synthetic strategies, with the latter providing the greatest flexibility for diversification at the 5-position at the last step of the synthesis.
