Title of article :
An unexpected ring contraction of two nitroaryl pro-drugs: conversion of N-(nitroaryl)-3-chloropiperidine derivatives into N-(nitroaryl)-2-chloromethylpyrrolidines
Author/Authors :
Burke، نويسنده , , Philip J. and Wong، نويسنده , , Lai Chun and Clegg، نويسنده , , William and Harrington، نويسنده , , Ross W. and Jenkins، نويسنده , , Terence C. and Knox، نويسنده , , Richard J. and Meikle، نويسنده , , Ian T. and Stanforth، نويسنده , , Stephen P.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Pages :
4
From page :
3918
To page :
3921
Abstract :
Treatment of the N-nitroaryl-3-hydroxypiperidine derivatives 12 and 13 with thionyl chloride afforded the corresponding N-aryl-2-chloromethylpyrrolidines 5 and 15 via a ring-contraction process involving an intermediate aziridinium ion.
Keywords :
Nitroaromatic pro-drugs , aziridinium ions , NAD(P)H: quinone oxidoreductase 1 , CB1954 , NQO1 , SN-23862
Journal title :
Tetrahedron Letters
Serial Year :
2010
Journal title :
Tetrahedron Letters
Record number :
1873688
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1873688
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