Author/Authors :
Zhang، نويسنده , , Haibo and Du، نويسنده , , Xue-Wei Pu، نويسنده , , Jianxin and Wang، نويسنده , , Yuan-Yuan and He، نويسنده , , Fei and Zhao، نويسنده , , Yong and Li، نويسنده , , Xiao-Nian and Luo، نويسنده , , Xiao and Xiao، نويسنده , , Weilie and Li، نويسنده , , Yan and Sun، نويسنده , , Han-Dong، نويسنده ,
Abstract :
Two novel diterpenoids, luanchunins A (1) and B (2), along with their precursor, kamebakaurin (3), had been isolated from the stems and leaves of Isodon rubescens var. lushanensis. Their structures were elucidated on the basis of extensive spectroscopic analyses. Compounds 1 and 2 showed potent cytotoxic activity against HL-60 with IC50 values of 4.81 μM and 3.52 μM, respectively. Plausible pathways for the biosynthesis of 1 and 2 were also postulated.
Keywords :
Isodon rubescens var. lushanensis , Diterpenoid , Luanchunin B , Luanchunin A
