The double addition reaction of alkoxymethyl nucleophiles to esters to generate novel polyoxygenated species

The development of a double addition reaction of alkoxylmethyl nucleophiles to a variety of functionalized aryl and alkyl esters to give polyoxygenated products is reported. Key features include broad electrophile substrate scope and good yields. Structurally diverse nucleophiles were investigated and were found to successfully undergo diaddition. This development now allows facile access to this novel class of polyoxygenated molecules.