Title of article
Histone deacetylase inhibitors: synthesis of cyclic tetrapeptides and their triazole analogs
Author/Authors
Singh، نويسنده , , Erinprit K. and Nazarova، نويسنده , , Lidia A. and Lapera، نويسنده , , Stephanie A. and Alexander، نويسنده , , Leslie D. and McAlpine، نويسنده , , Shelli R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
4357
To page
4360
Abstract
Synthesis of nine macrocyclic peptide HDAC inhibitors and three triazole derivatives is described. HDAC inhibitory activity of these compounds against HeLa cell lysate is evaluated. The biological data demonstrate that incorporation of a triazole unit improves the HDAC inhibitory activity.
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1874066
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