Histone deacetylase inhibitors: synthesis of cyclic tetrapeptides and their triazole analogs
Author/Authors :
Singh، نويسنده , , Erinprit K. and Nazarova، نويسنده , , Lidia A. and Lapera، نويسنده , , Stephanie A. and Alexander، نويسنده , , Leslie D. and McAlpine، نويسنده , , Shelli R.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Pages :
4
From page :
4357
To page :
4360
Abstract :
Synthesis of nine macrocyclic peptide HDAC inhibitors and three triazole derivatives is described. HDAC inhibitory activity of these compounds against HeLa cell lysate is evaluated. The biological data demonstrate that incorporation of a triazole unit improves the HDAC inhibitory activity.
