Title of article
Highly regioselective synthesis of glycospiro heterocycles through 1,3-dipolar cycloaddition reaction
Author/Authors
Prasanna، نويسنده , , R. and Purushothaman، نويسنده , , S. and Raghunathan، نويسنده , , R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
5
From page
4538
To page
4542
Abstract
A highly regio-selective synthesis of novel glycospiropyrrolidines has been accomplished by 1,3-dipolar cycloaddition (1,3-DC) reaction. A unique dipolarophile derived from galactose has been reacted with azomethine ylide generated from 1,2-diketones and secondary aminoacids to give the corresponding spiro glycoheterocycles in good yields. The structures were assigned by 2D NMR spectra and the regio- and stereochemical outcome of the cycloadducts was established by a single crystal X-ray analysis.
Keywords
Glyco-heterocycles , azomethine ylides , 1 , 3-DC reaction , Spiropyrrolidine
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1874212
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