Title of article
Synthesis of p38 MAP kinase inhibitor BIRB 796 and analogs via copper-mediated N-arylation reaction
Author/Authors
Tan، نويسنده , , Zhulin and Song، نويسنده , , Jinhua J. and Reeves، نويسنده , , Jonathan T. and Fandrick، نويسنده , , Daniel R. and Lee، نويسنده , , Heewon and Campbell، نويسنده , , Scot and Yee، نويسنده , , Nathan K.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
5
From page
4547
To page
4551
Abstract
Direct N-arylation of urea (5) with various arylboronic acids mediated by cupric acetate furnished BIRB796 and a range of N-substituted BIRB796 analogs in good to moderate yields in one step. Urea (5) was readily synthesized from commercially available compounds.
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1874222
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