Title of article
A straightforward synthesis and partial hydrolysis of cysteine-derived 2,5-diketopiperazines
Author/Authors
Iannotta، نويسنده , , Daniela and Castellucci، نويسنده , , Nicola and Monari، نويسنده , , Magda and Tomasini، نويسنده , , Claudia، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
2
From page
4558
To page
4559
Abstract
A mild and straightforward preparation of cysteine-derived 2,5-diketopiperazines (DKPs) is reported, by cyclization of (R)-2,2-dimethyltetrahydrothiazole-4-carboxylic acid hydrochloride or of (R)-tetrahydrothiazole-4-carboxylic acid hydrochloride, mediated by HBTU and DIEA. One DKP has been characterized by X-ray analysis, while the other has been hydrolyzed to cyclo-Cys-Cys. The preparation of this latter compound has been previously reported to be troublesome and low yielding.
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1874234
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