Author/Authors :
Matsuoka، نويسنده , , Shigeru and Mizoguchi، نويسنده , , Yuki and Itoh، نويسنده , , Hiroaki and Okura، نويسنده , , Ken-ichi Shinohara، نويسنده , , Naoki and Inoue، نويسنده , , Masayuki، نويسنده ,
Abstract :
l-β,β-Dimethylmethionine S-oxide is a unique amino acid found in polytheonamides. Four designed hexapeptides containing the sulfide, (SR)-sulfoxide, (SS)-sulfoxide, and sulfone derivatives of l-dimethylmethionine were synthesized and functionally analyzed. Our results indicate that the sulfoxide stereochemistry of the peptides controls their overall physicochemical properties.
