Title of article :
A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5-a]pyridines
Author/Authors :
Ducray، نويسنده , , Richard and Boutron، نويسنده , , Pascal and Didelot، نويسنده , , Myriam and Germain، نويسنده , , Hervé and Lach، نويسنده , , Franck and Lamorlette، نويسنده , , Maryannick and Legriffon، نويسنده , , Antoine and Maudet، نويسنده , , Mickael and Ménard، نويسنده , , Morgan and Pasquet، نويسنده , , Georges and Renaud، نويسنده , , Fabrice and Simpson، نويسنده , , Iain M. Young، نويسنده , , Gail، نويسنده ,
Abstract :
A two-step synthesis of 3-(2-chloropyrimidin-4-yl)imidazo[1,2-a]pyridines is presented. The late stage elaboration of the imidazopyridine through a cyclocondensation allows a rapid access to a variety of substitution patterns. The intermediate enol ethers were obtained from inexpensive reagents in a ligand-free Heck coupling. This methodology has been extended to the formation of pyrazolo[1,5-a]pyridines via a formal 1,3-dipolar cycloaddition.
