Title of article
Mild and convenient one-pot synthesis of 1,3,4-oxadiazoles
Author/Authors
Stabile، نويسنده , , Paolo and Lamonica، نويسنده , , Alessandro and Ribecai، نويسنده , , Arianna and Castoldi، نويسنده , , Damiano and Guercio، نويسنده , , Giuseppe and Curcuruto، نويسنده , , Ornella، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
5
From page
4801
To page
4805
Abstract
A mild, general, convenient, and efficient one-pot synthesis of 2-phenyl-5-substituted-1,3,4-oxadiazoles is described. Both (hetero)aryl and alkyl carboxylic acids were efficiently condensed with benzohydrazide in the presence of TBTU to give diacylhydrazine intermediates. The latter underwent a smooth TsCl-mediated cyclodehydration reaction to afford 2-phenyl-5-substituted-1,3,4-oxadiazoles in good to very good yields.
Keywords
1 , 3 , 4-oxadiazoles , cyclodehydration , Tosyl chloride , one-pot synthesis
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1874449
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