A green approach for the electrochemical synthesis of 4-morpholino-2-(arylsulfonyl)benzenamines

Electrochemical synthesis of 4-morpholino-2-arylsulfonyl-benzamines was carried out by the electrochemical oxidation of 4-morpholinoaniline in the presence of arenesulfinic acids at a carbon electrode, in aqueous solution. Our voltammetric data indicate that electrochemically generated p-quinone-diimine participates in Michael type addition reaction with arenesulfinic acids and via an EC mechanism converts to the title products. This method provides a green, one-pot procedure for the synthesis of 4-morpholino-2-(arylsulfonyl)benzenamines of potential biological significance.