Title of article
Highly enantioselective addition of linear alkyl alkynes to linear aldehydes
Author/Authors
Du، نويسنده , , Yuhao and Turlington، نويسنده , , B. Mark and Zhou، نويسنده , , Xiang and Pu، نويسنده , , Lin، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
5024
To page
5027
Abstract
It is discovered that the use of biscyclohexylamine (Cy2NH) as an additive can greatly enhance the enantioselectivity for the reaction of linear alkyl alkynes with linear aldehydes. The combination of (S)-BINOL (20 mol %), Cy2NH (5 mol %), ZnEt2 (2 equiv), and Ti(OiPr)4 (0.5 equiv) catalyzes the reaction at room temperature in diethyl ether solution with 81–89% ee and 57–77% yield.
Keywords
Binol , Chiral propargylic alcohols , Asymmetric catalysis , Alkynes , Aldehydes
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1874656
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