Title of article
Synthesis and cytotoxic evaluation of cis-locked and constrained analogues of combretastatin and combretastatin A4
Author/Authors
Magali M. Lorion، نويسنده , , Magali and Agouridas، نويسنده , , Vangelis and Couture، نويسنده , , Axel and Deniau، نويسنده , , Eric and Grandclaudon، نويسنده , , Pierre، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
5146
To page
5149
Abstract
A series of cis-locked stilbenic compounds related to combretastatin and combretastatin A4 has been designed and synthesized. The cytotoxic effects of these rigid analogues were evaluated as well as their abilities to inhibit tubulin polymerization.
Keywords
isoindolinones , Oxygen heterocycle , Oxidation , Anticancer agents , Combretastatins
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1874763
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