Title of article
Fatty acid amide hydrolase inhibitors. 2. Novel synthesis of sterically hindered azabenzhydryl ethers and an improved synthesis of VER-156084
Author/Authors
Roughley، نويسنده , , Stephen D. and Hart، نويسنده , , Terance، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
5191
To page
5194
Abstract
We report an improved synthesis of the fatty acid amide hydrolase (FAAH) inhibitor VER-156084. The key step is a novel, environmentally benign etherification to form an unusual, highly hindered azabenzhydryl ether. The method is applied to a variety of primary and secondary alcohols.
Keywords
Azetidine ether , Hindered ether , green chemistry , Azabenzhydryl ether , Fatty acid amide hydrolase (FAAH) inhibitor , etherification
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1874803
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