Title of article
First synthesis and full characterization of mexiletine N-carbonyloxy β-d-glucuronide
Author/Authors
P. Cavalluzzi، نويسنده , , Maria Maddalena and Lentini، نويسنده , , Giovanni and Lovece، نويسنده , , Angelo and Bruno، نويسنده , , Claudio and Catalano، نويسنده , , Alessia and Carocci، نويسنده , , Alessia and Franchini، نويسنده , , Carlo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
5265
To page
5268
Abstract
A simple, convergent synthesis of the N-carbonyloxy β-d-glucuronide of mexiletine (sodium salt) in moderate yield is described. The compound is now available as an authentic reference standard for analytical studies, enabling more detailed investigation on the metabolism of mexiletine.
Keywords
Glycosidic linkage , Ring-opening reaction , Curtius rearrangement , Stereochemistry
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1874850
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