Author/Authors :
Watanabe، نويسنده , , Shin-ichi and Hasebe، نويسنده , , Risa and Ouchi، نويسنده , , Jun and Nagasawa، نويسنده , , Hideko and Kataoka-Shirasugi، نويسنده , , Tadashi، نويسنده ,
Abstract :
Asymmetric Darzens reaction catalyzed by chiral selenides is described. A novel Lewis acid/Brّnsted base catalyst formed by C2 symmetric chiral selenide-bearing isoborneol skeletons, which were readily prepared from (1S)-10-camphorsulfonic acid, and LiOH promoted the reaction of phenacyl bromide with aldehydes to afford the desired trans oxiranes with up to 62% ee.
