Straightforward hetero Diels–Alder reactions of nitroso dienophiles by microreactor technology

The hetero Diels–Alder reactions of 2-nitrosotoluene and some representative acylnitrosodienophiles with a selected set of 1,3-dienes were studied under microflow conditions. The main assets of the technology, that is, an accurate control of the reaction parameters and continuous operating, led to an increased efficiency of this reaction.