Author/Authors :
Fu، نويسنده , , Shaomin and Lian، نويسنده , , Xiaoyan and Ma، نويسنده , , Tongmei and Chen، نويسنده , , Wenhua and Zheng، نويسنده , , Meifang and Zeng، نويسنده , , Wei، نويسنده ,
Abstract :
Several Lewis acids were investigated as promoters in the intermolecular or intramolecular direct N-acylation reaction of sulfonamides using carboxylic ester as an acylating agent. TiCl4 was found to possess the highest activity and enhanced efficiently sulfonamide to form N-acylsulfonamides under optimized conditions. This method provides a novel approach to make N-acylsulfonamides from ester via an easy work-up procedure.
Keywords :
N-acylation , N-Acylsulfonamide , Carboxylic ester , Lewis acid , acylating agents
