Author/Authors :
Voight، نويسنده , , Eric A. and Daanen، نويسنده , , Jerome F. and Hannick، نويسنده , , Steven M. and Shelat، نويسنده , , Bhadra H. and Kerdesky، نويسنده , , Francis A. and Plata، نويسنده , , Daniel J. and Kort، نويسنده , , Michael E.، نويسنده ,
Abstract :
Starting from a variety of substituted chroman-4-ones, a highly enantioselective CBS reduction using in situ-generated B–H catalyst gave (S)-chroman-4-ols. Azide inversion and reduction gave crude (R)-chroman-4-amines, which could be purified without chromatography by isolation as the (R)-mandelic or d-tartaric acid salts with good yields and excellent ee.
