Title of article
Tandem three-component reaction of aldehyde, alkyl acrylate, and amide using ethyl diphenylphosphine as organocatalyst
Author/Authors
Syu، نويسنده , , Siang-En and Wang، نويسنده , , Dewei and Chen، نويسنده , , Pei-Yi and Hung، نويسنده , , Yi-Ting and Jhang، نويسنده , , Yi-Wun and Kao، نويسنده , , Tzu-Ting and Lee، نويسنده , , YuTing and Lin، نويسنده , , Wenwei، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
5943
To page
5946
Abstract
It is the first time that a chemoselective EtPPh2-catalyzed three-component reaction of aromatic aldehyde, alkyl acrylate, and phthalimide or methyl toluenesulfonamide has been achieved. A variety of highly functional adducts can be generated efficiently in one step within 1–72 h in 38–93% yields. The reaction mechanism is proposed to undergo Morita–Baylis–Hillman reactions of aryl-substituted aldehydes and alkyl acrylates followed by Michael additions of amides. Our studies indicated that, in combination of EtPPh2, alkyl acrylate also catalyzed this process.
Keywords
Michael addition , aldehyde , multicomponent reaction , Chemoselectivity , Morita–Baylis–Hillman
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1875415
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